Prof. Winchester obtained a Ph.D. in molecular enzymology in the Biochemistry Department at University College London after graduating from Cambridge University in Chemistry.
Subsequently he became a lecturer in Biochemistry at Queen Elizabeth College (QEC), London University, where he developed his interest in lysosomal storage diseases and glycobiology working with Don Robinson.
He stayed at QEC for 22 years before moving to the Institute of Child Health (University College London) at Great Ormond Street Hospital in 1988, as successor to Des Patrick.
During his time at QEC, Bryan spent a sabbatical year working with Bob Jolly in New Zealand on animal models of the LSD’s and a shorter period with Peter Dorling in Australia working on the biological effects of the amino sugar, swainsonine. The latter project led to a long-standing collaboration with George Fleet in Chemistry at Oxford University, UK. He also spent short periods working with Arnold Reuser in Hans Galjaard’s laboratory, with Joseph Tager in the Netherlands and with Chris Warren and Peter Daniel in Boston, USA.
At the Institute of Child Health, Bryan was responsible for direction of the Enzyme Diagnostic Laboratory and for the research infrastructure for a team of paediatric metabolic physicians and scientists investigating the molecular basis and developing novel forms of therapy for genetic metabolic diseases. His own research concentrates on the lysosomal storage diseases and another group genetic metabolic diseases, the congenital disorders of glycosylation.
He is Chairman of the European Study Group on Lysosomal Diseases and of the UK Lysosomal Storage Diseases Management Group.